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Journal: medRxiv
Article Title: The Impact of Cognitive Function on Health-Related Quality of Life in Persons with Post-COVID-19 Condition: A Randomized Controlled Trial on Vortioxetine
doi: 10.1101/2024.03.18.24304375
Figure Lengend Snippet: An intention-to-treat GEE analysis examining the effects of vortioxetine ( n = 73) versus placebo ( n = 74) on how cognitive function (combined DSST z-score) impacts health-related quality of life (WHO-5 total score) in an 8-week trial involving participants with PCC. There was a significant effect of time with both groups, exhibiting significant improvement in WHO-5 total score across treatment weeks ( p < 0.001). Moreover, a significant group effect (p = 0.047), treatment by time interaction effect ( p = 0.012), and treatment by time by combined DSST z-score interaction effect ( p = 0.004) was observed. Depicted is the least square (LS) mean (standard error of mean [SEM]) change in WHO-5 from baseline to endpoint using an independent covariance matrix with time as a categorical variable, adjusted for the type of cognitive test (Pen/Paper vs. Online CogState Version).
Article Snippet: If the
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